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1

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

Stephen Hanessian, Kandasamy Pachamuthu, Janek Szychowski, Alexandre Giguère, Eric E. Swayze, Michael T. Migawa, Boris François, Jiro Kondo, Eric Westhof

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 461 KB

english, 2010

2

Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Nair, Jayaprakash K., Willoughby, Jennifer L. S., Chan, Amy, Charisse, Klaus, Alam, Md. Rowshon, Wang, Qianfan, Hoekstra, Menno, Kandasamy, Pachamuthu, Kel’in, Alexander V., Milstein, Stuart, Taneja,

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

3

An Easy Route to 2-Amino-β-C-Glycosides by Conjugate Addition to 2-Nitroglycals

Kandasamy Pachamuthu, Anuradha Gupta, Jagattaran Das, Richard R. Schmidt, Yashwant D. Vankar

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 287 KB

english, 2002

4

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Boris François, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Eric E. Swayze, Richard H. Griffey, Michael T. Migawa, Eric Westhof, Stephen Hanessian

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 237 KB

english, 2004

5

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Boris François, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Eric E. Swayze, Richard H. Griffey, Michael T. Migawa, Eric Westhof, Stephen Hanessian

Journal:

Angewandte Chemie

Year:

2007

File:

PDF, 27 KB

2007

6

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Boris François, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Eric E. Swayze, Richard H. Griffey, Michael T. Migawa, Eric Westhof, Stephen Hanessian

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

7

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Boris François, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Eric E. Swayze, Richard H. Griffey, Michael T. Migawa, Eric Westhof, Stephen Hanessian

Journal:

Angewandte Chemie International Edition

Year:

2007

File:

PDF, 28 KB

2007

8

ChemInform Abstract: Ceric Ammonium Nitrate Catalyzed Tetrahydropyranylation of Alcohols and Synthesis of 2-Deoxy-O-glycosides.

Kandasamy Pachamuthu, Yashwant D. Vankar

Journal:

Year:

2002

File:

PDF, 32 KB

2002

9

ChemInform Abstract: An Easy Route to 2-Amino-β-C-glycosides by Conjugate Addition to 2-Nitroglycals.

Kandasamy Pachamuthu, Anuradha Gupta, Jagattaran Das, Richard R. Schmidt, Yashwant D. Vankar

Journal:

Year:

2002

File:

PDF, 34 KB

2002

10

Synthesis of Methionine-Containing Peptides Related to Native Chemical Ligation.

Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2003

File:

PDF, 116 KB

2003

11

Diels—Alder Reaction of 2-Nitro Glycals: A New Route to the Synthesis of Benzopyrans.

Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2003

File:

PDF, 146 KB

2003

12

A Convenient Route to O-Glycosyl Lactates via Conjugate Addition to 2-Nitroglycals: Ring Closure to Novel Pyrano[2.3-b][1,4]-oxazines.

Ahmed I. Khodair, Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2004

File:

PDF, 131 KB

2004

13

Synthesis of Novel S-Neoglycopeptides from Glycosylthiomethyl Derivatives.

Xiangming Zhu, Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2004

File:

PDF, 50 KB

2004

14

Straightforward Synthesis of gem-Phosphonate-Phosphate Containing Compounds via One-Pot Reaction of Thioesters with Diethyl Phosphite.

Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2004

File:

PDF, 113 KB

2004

15

Synthesis of Glycosyl Phosphonates by Michael-Type Addition to 2-Nitroglycals.

Kandasamy Pachamuthu, Ignacio Figueroa-Perez, Ibrahim A. I. Ali, Richard R. Schmidt

Journal:

Year:

2005

File:

PDF, 33 KB

2005

16

Michael-Type Addition to 2-Nitrogalactal — A Simple Method to Access 1,1-Linked Oligosaccharides.

Rengarajan Balamurugan, Kandasamy Pachamuthu, Richard R. Schmidt

Journal:

Year:

2005

File:

PDF, 31 KB

2005

17

Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity

Jiro Kondo, Kandasamy Pachamuthu, Boris François, Janek Szychowski, Stephen Hanessian, Eric Westhof

Journal:

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007

18

Synthesis of Glycosyl Phosphonates by Michael-Type Addition to 2-Nitroglycals

Kandasamy Pachamuthu, Ignacio Figueroa-Perez, Ibrahim A. I. Ali, Richard R. Schmidt

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 84 KB

english, 2004

19

Synthesis of (−)-coniine and (−)-pipecoline using ruthenium catalyzed ring closing metathesis

Kandasamy Pachamuthu, Yashwant D Vankar

Journal:

Journal of Organometallic Chemistry

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

20

Erratum to “Synthesis of (−)-coniine and (−)-pipecoline using ruthenium catalyzed ring closing metathesis”: Journal of Organometallic Chemistry 624 (2001) 359–363

Kandasamy Pachamuthu, Y.D Vankar

Journal:

Journal of Organometallic Chemistry

Year:

2002

Language:

english

File:

PDF, 42 KB

english, 2002

21

Synthetic Routes to Thiooligosaccharides and Thioglycopeptides

Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Chemical Reviews

Year:

2006

Language:

english

File:

PDF, 1.26 MB

english, 2006

22

Ceric Ammonium Nitrate-Catalyzed Tetrahydropyranylation of Alcohols and Synthesis of 2-Deoxy-O-Glycosides

Pachamuthu, Kandasamy, Vankar, Yashwant D.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 56 KB

english, 2001

23

Synthesis of novel pyrazolylbiscoumarin derivatives using FeTUD-1 as a mesoporous solid acid catalyst

Kandasamy, Karthikeyan, Pachamuthu, Muthusamy Poomalai, Muthusamy, Manimaran, Ganesabaskaran, Sivaprasad, Ramanathan, Anand

Journal:

Year:

2013

Language:

english

File:

PDF, 1.00 MB

english, 2013

24

Reversed Approach to S -Farnesylation and S -Palmitoylation: Application to an Efficient Synthesis of the C-Terminus of Lipidated Human N-Ras Hexapeptide

Pachamuthu, Kandasamy, Zhu, Xiangming, Schmidt, Richard R.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 127 KB

english, 2005

25

Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2‘ ‘ Ether Analogues of Paromomycin

Hanessian, Stephen, Szychowski, Janek, Adhikari, Susanta Sekhar, Vasquez, Guillermo, Kandasamy, Pachamuthu, Swayze, Eric E., Migawa, Michael T., Ranken, Ray, François, Boris, Wirmer-Bartoschek, Julia,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 570 KB

english, 2007

26

Synthesis of S -Linked Glycopeptides in Aqueous Solution

Zhu, Xiangming, Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Journal of Organic Chemistry

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

27

Synthesis of Novel S -Neoglycopeptides from Glycosylthiomethyl Derivatives

Zhu, Xiangming, Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 94 KB

english, 2004

28

Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphiteElectronic supplementary information (ESI) available: physical data of new compounds. See http://www.rsc.org/suppdata/cc/b4/b401079e/

Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

29

siRNA Conjugates Carrying Sequentially Assembled Trivalent N- Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

Matsuda, Shigeo, Keiser, Kristofer, Nair, Jayaprakash K., Charisse, Klaus, Manoharan, Rajar M., Kretschmer, Philip, Peng, Chang G., V. Kel’in, Alexander, Kandasamy, Pachamuthu, Willoughby, Jennifer L.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.12 MB

english, 2015

30

A novel pyrazole biscoumarin based chemosensors for the selective detection of Cu2+ and Zn2+ ions

Kandasamy, Karthikeyan, Ganesabaskaran, Sivaprasad, Pachamuthu, Muthusamy Poomalai, Ramanathan, Anand

Journal:

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

31

Synthesis of pyrazolylbisindoles over mesoporous Lewis acidic ZrTUD-1: Potential application in selective Cu2+ colorimetric detection

Kandasamy, Karthikeyan, Ganesabaskaran, Sivaprasad, Pachamuthu, Muthusamy Poomalai, Maheswari, Rajamanickam, Ramanathan, Anand

Journal:

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Year:

2015

Language:

english

File:

PDF, 975 KB

english, 2015

32

Diels-Alder Reactionof 2-Nitro Glycals: A New Route to the Synthesis of Benzopyrans

Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Year:

2003

Language:

english

File:

PDF, 57 KB

english, 2003

33

Michael-Type Addition to 2-Nitrogalactal - A Simple Method to Access 1,1-Linked Oligosaccharides

Balamurugan, Rengarajan, Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Year:

2005

Language:

english

File:

PDF, 1.83 MB

english, 2005

34

A Convenient Route to O -Glycosyl Lactates via Conjugate Addition to 2-Nitroglycals: Ring Closure to Novel Pyrano[2.3- b ][1,4]-oxazines

Khodair, Ahmed, Pachamuthu, Kandasamy, Schmidt, Richard

Journal:

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

35

Synthesis of Methionine ContainingPeptides Related to Native Chemical Ligation

Pachamuthu, Kandasamy, Schmidt, Richard R.

Journal:

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

36

THE INVESTIGATIONAL STEREOPURE ANTISENSE OLIGONUCLEOTIDE WVE-3972-01 PREFERENTIALLY REDUCES G4C2 REPEAT-CONTAINING C9ORF72 TRANSCRIPTS: A POTENTIAL THERAPEUTIC APPROACH FOR THE TREATMENT OF FRONTOTEMPORAL DEMENTIA

Dodart, Jean-Cosme, Liu, Yuanjing, Tran, Helene, Berkovitch, Shaunna, Byrne, Michael, Durbin, Ann, Iwamoto, Naoki, Jang, Hyun Gyung, Kandasamy, Pachamuthu, Liu, Fangjun, Mohapatra, Susovan, Yang, Hail

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 119 KB

english, 2018

37

THE INVESTIGATIONAL STEREOPURE ANTISENSE OLIGONUCLEOTIDE WVE-3972-01 PREFERENTIALLY REDUCES G4C2 REPEAT-CONTAINING C9ORF72 TRANSCRIPTS: A POTENTIAL THERAPEUTIC APPROACH FOR THE TREATMENT OF FRONTOTEMPORAL DEMENTIA

Dodart, Jean-Cosme, Liu, Yuanjing, Tran, Helene, Berkovitch, Shaunna, Byrne, Michael, Durbin, Ann, Iwamoto, Naoki, Jang, Hyun Gyung, Kandasamy, Pachamuthu, Liu, Fangjun, Mohapatra, Susovan, Yang, Hail

Journal:

Alzheimer's & Dementia

Year:

2018

File:

PDF, 119 KB

2018